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Isotonix® Digestive Enzymes with Probiotics (Packets)

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Isotonix Digestive Enzymes Advantage

What Makes Isotonix Digestive Enzymes with Probiotics Unique?

Processed foods are the norm these days, not making it any easier for your body to digest and take in all the essential nutrients you need. Foods that would otherwise offer us their own added enzymes to help our bodies absorb more nutrients are increasingly processed, heated for extended shelf life and stripped of vital elements. Other poor eating habits and even aging can also contribute to inhibiting a healthy digestive process. This means our bodies may now need to work harder to absorb essential nutrients to keep us healthy and functioning. Isotonix® Digestive Enzymes with Probiotics was designed to provide your body with enzymes and good bacteria to promote the absorption of nutrients. It utilizes our advanced Isotonix delivery system to provide you with essential nutrients that promote digestive health.*

This digestive health-promoting supplement features a formula of digestive enzymes and probiotics, including DigeZyme® – a blend of amylase, protease, cellulase, lactase and lipase - and Lactospore®† (Bacillus coagulans). Digestive enzymes help your body break down food to utilize the complete spectrum of nutrients in the food you eat, resulting in a more complete digestive process and better nutritional absorption. The addition of probiotics helps promote a healthy intestinal tract environment. Besides supporting a healthy digestive tract and absorption of nutrients, Isotonix Digestive Enzymes with Probiotics helps maintain epithelial structure and barrier function and supports healthy skin, helps maintain healthy cholesterol levels, supports healthy immune functions, and may help ease occasional stomach upset.* Isotonix Digestive Enzymes with Probiotics helps keep your digestive health on track! Its unique blend of digestive enzymes and probiotics makes supporting your digestive health efficient and convenient.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

As DigeZyme®. DigeZyme is a registered trademark of the Sabinsa Corporation.

DU, PC, CU, LAC, LIP, and SU are units of enzyme activity.

§As Lactospore®. Lactospore is a registered trademark of the Sabinsa Corporation.

CFU = colony-forming units.

What Makes Isotonix Digestive Enzymes with Probiotics Unique?

Primary Benefits* of Isotonix® Digestive Enzymes with Probiotics (Packets)

Transform food into energy.

  • Helps maintain healthy cholesterol levels
  • May help ease occasional stomach upset
  • Promotes digestion and absorption of nutrients 
  • Provides enzymes and good bacteria that promote the digestion and absorption of nutrients
  • Supports a healthy digestive tract
  • Supports healthy immune functions
  • Helps maintain normal skin
  • Supports healthy skin
  • Helps maintain the epithelial structure and barrier function

Product Classifications

Gluten-Free - The finished product contains no detectable gluten (<10ppm gluten)

No Detectable GMOs - The finished product contains no detectable genetically-modified organisms

Vegan - The product is made without ingredients produced by or derived from animals

Isotonic-Capable Drinkable Supplements - Easy-to-swallow supplements in liquid form are immediately available to the body for absorption

Quality Standards - GMP Operations and Standardized Ingredients

Checked For: Heavy Metals, Microbiological Contaminants, Allergens, Residual Solvents, Potency, Purity and Identity

Isotonix Delivery System

Isotonix Delivery System

Isotonix - the World's Most Advanced Nutraceuticals
Isotonic, which means “same pressure,” bears the same chemical resemblance of the body’s blood, plasma and tears. All fluids in the body have a certain concentration, referred to as osmotic pressure. The body’s common osmotic pressure, which is isotonic, allows a consistent maintenance of body tissues. In order for a substance to be absorbed and used in the body’s metabolism, it must be transported in an isotonic state.

Isotonix dietary supplements are delivered in an isotonic solution. This means that the body has less work to do in obtaining maximum absorption. The isotonic state of the suspension allows nutrients to pass directly into the small intestine and be rapidly absorbed into the bloodstream. With Isotonix products, little nutritive value is lost, making the absorption of nutrients highly efficient while delivering maximum results.

Key Ingredients

DigeZyme® [Amylase, Protease, Cellulase, Lactase, Lipase)
DigeZyme® is a multienzyme complex composed mainly of amylases (starch hydrolyzing enzymes), proteases (protein hydrolyzing enzymes) and lipases (lipid hydrolyzing enzymes). These digestive enzymes collectively support the breakdown of complex macromolecules into energy sources and promote the release of the nutrient content from the foods we eat. The digestive system naturally produces digestive enzymes. DigeZyme® supplements the gastrointestinal tract with enzymes to adequately support the body’s ability to digest food. In addition to the amylases, proteases, and lipases, DigeZyme® contains two additional digestive enzymes including lactase (lactose hydrolyzing enzyme) and cellulase (cellulose hydrolyzing enzyme).*

Sucrase is a digestive enzyme secreted by the villi of the epithelium in the small intestine that supports the hydrolysis (chemical breakdown) of sucrose, also known as table sugar, into glucose and fructose. Glucose and fructose can then enter the blood stream and be used for energy.*

Magnesium (Carbonate)
Magnesium promotes the normal synthesis of all proteins, nucleic acids, nucleotides, cyclic adenosine monophosphate, lipids and carbohydrates. Magnesium also promotes cardiovascular health by supporting normal platelet activity, helping to maintain normal cholesterol levels, and helping to maintain the normal regulation of the heart and blood pressure.* 

Potassium (Bicarbonate)
Potassium is an essential macro-mineral that helps maintain fluid balance. It promotes normal synthesis of glycogen and proteins, as well as the proper release of energy from protein, fat and carbohydrates during metabolism metabolization. Potassium also promotes the normal elimination of wastes and generally contributes to a sense of well-being. Potassium is stored in the muscles.*

Bacillus coagulans (Lactospore®)
Previously known as Lactobacillus sporogenesBacillus coagulans is a lactic acid producing bacteria. Even though it produces lactic acid, it is not a lactic acid bacteria (i.e. lactobacillus).1 B. coagulans also produce reproductive spores, which sets it apart from many other probiotics.1 It has shown to survive high levels of stomach acid, which means that it arrives to the small intestine as live bacteria so that it may provide health benefits.1 Research has shown B. coagulans to promote digestive and gastrointestinal health.*


  1. What happens when we eat?
    Even before we eat, our body‘s digestive action begins to take place. Simply smelling food activates our salivary glands ("mouth watering"). As the food enters the stomach, the stomach acid and pepsin – the main digestive enzyme in the stomach – work together to begin breaking the food down into material that the small intestine, where most nutrients are absorbed, can use. Enzymes specific to each of the three nutrient groups (carbohydrates, proteins and fats) are released at this stage, further breaking down the food and contributing to the digestive and absorption processes. These processes continue into the large intestine until the nutrients are extracted by the body.

  2. What are digestive enzymes?
    Digestive enzymes help your body break down food, allowing the body to optimize its effort to digest proteins from plant and animal sources as well as break down starch, lactose, fats, and nucleic acids (DNA and RNA). The result is a more complete digestive process, resulting in better nutritional absorption. While most enzymes work inside our cells, digestive enzymes operate outside the cells in the gastrointestinal tract.*

  3. What are the different types of digestive enzymes?
    There are three basic food enzymes, each specifically targeting the digestion of a different kind of food molecule: Protease, which helps digest proteins, amylase, which helps digest starch, and lipase, which helps digest fats. There are also four specialty enzymes: lactase (helps digest the sugar lactose in dairy products), maltase (helps digest the sugar maltose in foods), sucrase (helps digest table sugar and sugar found in fruits), and cellulase (helps digest cellulose fibers). Each of these enzymes plays a significant part in the body’s overall health by helping to release specific and necessary nutrients into our bodies.*

  4. What are probiotics? 
    Probiotics are beneficial bacteria that are widely believed to provide numerous health benefits, including promoting digestive and immune health. Our bodies all contain both “good” and “bad” bacteria in our digestive system. Probiotics are a heavily researched option for maintaining a healthy balance of bacteria. Isotonix® Digestive Enzymes with Probiotics contains the probiotic, Bacillus coagulans. B. coagulans produces lactic acid, but is not considered a lactic acid bacteria.1 *

  5. Is this a vegetarian product?

  6. What is the best way to store this product?
    Keep Isotonix stored in a dry, cool place. If Isotonix are stored in the kitchen, keep them away from the stove, sink, heat-generating appliances or window ledges. If you live in a very humid area, you may store Isotonix products in the refrigerator – but not in the fruit and vegetables area.


  • Anonymous. Lactobacillus Sporogenes. Alternative Medical Review. 7(4): 340-342, 2002.
  • Bourlioux, P., et al. The Intestine and Its Microflora are Partners for the Protection of the host: Report on the Danone Symposium “The Intelligent Intestine,” Held in Paris, June 14, 2002. American Journal of Clinical Nutrition. 78: 675-683, 2003.
  • Casula, G. and Cutting, S. Bacillus Probiotics: Spore Germination in the Gastrointestinal Tract. Applied and Environmental Microbiology. 68(5): 2344-2352, 2002.
  • De Vecchi, E. and Drago, L. Lactobacillus Sporogenes or Bacillus Coagulans: Misidentification or Mislabeling? International Journal of Probiotics and Prebiotics. 1(1): 3-10, 2006.
  • Feinle-Bisset, C., et al. Fat Digestion is Required for Suppression of Ghrelin and Stimulation of Peptide YY and Pancreatic Polypeptide Secretion by Intraduodenal Lipid. American Journal of Physiology: Endocrinology and Metabolism. 289: E948-E953, 2005.
  • Keller, J. and Layer, P. Human Pancreatic Exocrine Response to Nutrients in Health and Disease. Gut. 54: 1-28, 2005.
  • Lee, M., et al. Total Intestinal Lactase and Sucrase Activities Are Reduced in Aged Rats. Journal of Nutrition. 127(7): 1382-1387, 1997.
  • Meisel, J. Commensal microbiota modulate gene expression in the skin. Microbiome. 6(1): 20, 2018
  • Nichols, B., et al. The Maltase-Glucoamylase Gene: Common Ancestry to Sucrase-Isomaltase with Complementary Starch Digestion Activities. Proceedings of the National Academy of Sciences of the United States of America. 100(3): 1432-1437, 2003.
  • O’Dea, K., et al. Rate of Starch Hydrolysis in Vitro as a Predictor of Metabolic Responses to Complex Carbohydrate In Vivo. American Journal of Clinical Nutrition. 34: 1991-1993, 1981.
  • Sanders, M., et al. Sporeformers as Human Probiotics: Bacillus, Sporolactobacillus, and Brevibacillus. Comprehensive Reviews in Food Science and Food Safety. 2: 101- 110, 2003.
  • Scotti, E., et al. Exploring the microbiome in health and disease: Implications for toxicology. Toxicology Research and Application. doi: 10.1177/2397847317741884, 2017
  • Vaughn, A. R., et al. Skin-gut axis: The relationship between intestinal bacteria and skin health. World Journal of Dermatology. 6(4): 52-58, 2017


Customer Reviews
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by Anonymous

Digestive Enzymes

easy to drink and nice taste. not like tablet must swallow.


by GailH

great for travel

Traveling , especially on planes where size/volume of items matters. Having this great product in a travel size it perfect.

Response from Customer Service

Dear Valued Customer,

Thank you for your review! We are so glad to hear how useful the Isotonix® Digestive Enzymes with Probiotics (Packets) are! We strive to make products that work for your lifestyle and we’re pleased to know they are helpful for travelers. We strive to ensure that our products are always of the highest quality.

Thank you again!
The Product Information Team


by Pahrin AS

Digestive Enzymes with Probiotics

I have found pleasant relief with this Product. I am very satisfied.

Response from Customer Service

Dear Valued Customer,

Thank you for taking the time to share your thoughts on the nutraMetrix Isotonix® Digestive Enzymes with Probiotics! We are so happy to hear you are pleased with the product!

Thank you again!
The Product Information Team


by DianaS


Another fantastic and effective product for people like me w digestive challenges.

Response from Customer Service

Dear Valued Customer,

Thank you for taking the time to share your thoughts on the Isotonix® Digestive Enzymes with Probiotics (Packets)! We are so happy to hear you are pleased with the product!

Thank you again!
The Product Information Team



Product Review

Amazing product. It tastes great & it helps when I'm full after eating and an occasional stomach upset. I love the packets to have available in my purse.

Response from Customer Service

Dear Valued Customer,

Thank you for taking the time to share your thoughts on the Isotonix® Digestive Enzymes with Probiotics (Packets)! We are so happy to hear you are pleased with the product!

Thank you again!
The Product Information Team